Overcoming obstacles in Parkinson's disease.
Identifieur interne : 000C80 ( Main/Exploration ); précédent : 000C79; suivant : 000C81Overcoming obstacles in Parkinson's disease.
Auteurs : Todd B. Sherer [États-Unis] ; Sohini Chowdhury ; Katherine Peabody ; Deborah W. BrooksSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- economics : Clinical Trials as Topic, Parkinson Disease.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Humans.
Abstract
Improved symptomatic and disease-modifying treatments are needed for Parkinson's disease (PD). Although significant advances have been made in the understanding of PD etiology, the translation of these discoveries into novel transformative therapies has been limited as a result of systemic challenges in PD drug development. Preclinical testing lacks clear standards and prioritization criteria for advancing therapies to the clinic. Clinical testing is marked by expensive, long, and uninformative studies. In parallel to these scientific challenges, funding of late-stage drug development has become increasingly scarce and risk averse. In this context, novel models of collaboration and funding are opening up new avenues for pursuing treatments. This review will discuss the most critical challenges in PD drug development and the innovative approaches being developed to overcome these hurdles.
DOI: 10.1002/mds.25260
PubMed: 23115047
Affiliations:
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Le document en format XML
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Fox Foundation for Parkinson's Research, New York, New York 10163-4777</wicri:regionArea><wicri:noRegion>New York 10163-4777</wicri:noRegion></affiliation></author><author><name sortKey="Chowdhury, Sohini" sort="Chowdhury, Sohini" uniqKey="Chowdhury S" first="Sohini" last="Chowdhury">Sohini Chowdhury</name></author><author><name sortKey="Peabody, Katherine" sort="Peabody, Katherine" uniqKey="Peabody K" first="Katherine" last="Peabody">Katherine Peabody</name></author><author><name sortKey="Brooks, Deborah W" sort="Brooks, Deborah W" uniqKey="Brooks D" first="Deborah W" last="Brooks">Deborah W. 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Sherer</name><affiliation wicri:level="1"><nlm:affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, New York 10163-4777, USA. tsherer@michaeljfox.org</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Michael J. Fox Foundation for Parkinson's Research, New York, New York 10163-4777</wicri:regionArea><wicri:noRegion>New York 10163-4777</wicri:noRegion></affiliation></author><author><name sortKey="Chowdhury, Sohini" sort="Chowdhury, Sohini" uniqKey="Chowdhury S" first="Sohini" last="Chowdhury">Sohini Chowdhury</name></author><author><name sortKey="Peabody, Katherine" sort="Peabody, Katherine" uniqKey="Peabody K" first="Katherine" last="Peabody">Katherine Peabody</name></author><author><name sortKey="Brooks, Deborah W" sort="Brooks, Deborah W" uniqKey="Brooks D" first="Deborah W" last="Brooks">Deborah W. Brooks</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Trials as Topic (economics)</term><term>Humans</term><term>Parkinson Disease (economics)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term></keywords><keywords scheme="MESH" qualifier="economics" xml:lang="en"><term>Clinical Trials as Topic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Improved symptomatic and disease-modifying treatments are needed for Parkinson's disease (PD). Although significant advances have been made in the understanding of PD etiology, the translation of these discoveries into novel transformative therapies has been limited as a result of systemic challenges in PD drug development. Preclinical testing lacks clear standards and prioritization criteria for advancing therapies to the clinic. Clinical testing is marked by expensive, long, and uninformative studies. In parallel to these scientific challenges, funding of late-stage drug development has become increasingly scarce and risk averse. In this context, novel models of collaboration and funding are opening up new avenues for pursuing treatments. This review will discuss the most critical challenges in PD drug development and the innovative approaches being developed to overcome these hurdles.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Brooks, Deborah W" sort="Brooks, Deborah W" uniqKey="Brooks D" first="Deborah W" last="Brooks">Deborah W. Brooks</name><name sortKey="Chowdhury, Sohini" sort="Chowdhury, Sohini" uniqKey="Chowdhury S" first="Sohini" last="Chowdhury">Sohini Chowdhury</name><name sortKey="Peabody, Katherine" sort="Peabody, Katherine" uniqKey="Peabody K" first="Katherine" last="Peabody">Katherine Peabody</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B" last="Sherer">Todd B. Sherer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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